Clinicopathologic Factors and Nuclear Morphometry as Independent Prognosticators in KIT-positive Gastrointestinal Stromal Tumors
نویسندگان
چکیده
منابع مشابه
Nuclear morphometry and proliferative activity evaluation in the gastrointestinal stromal tumors.
Twenty-two cases with gastrointestinal stromal tumors (GISTs) have been studied, sized from 2 cm to invasive gigantic tumors and also from low to high degree of malignancy. The altering of the form and the size of the nucleus is a reference point of malignancy, being used in the histological grading of many types of tumors and also as an appreciating parameter of the tumoral prognosis, with a h...
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متن کاملFrequent KIT Mutations in Human Gastrointestinal Stromal Tumors
Identifying gene mutations in individual tumors is critical to improve the efficacy of cancer therapy by matching targeted drugs to specific mutations. Gastrointestinal stromal tumors (GIST) are stromal or mesenchymal subepithelial neoplasms affecting the gastrointestinal tract and frequently contain activating gene mutations in either KIT or platelet-derived growth factor A (PDGFRA). Although ...
متن کاملC-kit gene mutation in human gastrointestinal stromal tumors.
AIM To investigate the significance of c-kit gene mutation in gastrointestinal stromal tumors (GIST). METHODS Fifty two cases of GIST and 28 cases of other tumors were examined. DNA samples were extracted from paraffin sections and fresh blocks. Exons 11, 9 and 13 of the c-kit gene were amplified by PCR and sequenced. RESULTS Mutations of exon 11 were found in 14 of 25 malignant GISTs (56%)...
متن کاملFrequency of KIT Mutation in Gastrointestinal Stromal Tumors According to Histologic and Immunohistochemical Findings, the First Report from Iran
Background: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract. They are believed to originate from the interstitial cells of Cajal. Most of these tumors contain activating mutations in the KIT receptor tyrosine kinase. This is the first study in Iran to evaluate GISTs at the molecular level.Methods: In the present study, during 5 years (...
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ژورنال
عنوان ژورنال: Journal of Histochemistry & Cytochemistry
سال: 2007
ISSN: 0022-1554,1551-5044
DOI: 10.1369/jhc.7a7333.2007